| Rushing Leaders | ||||
| Name | Team | Yards | Rush/Avg | TDs |
| Larry Johnson | Kansas City | 1,799 | 5.3 | 17 |
| Shaun Alexander | Seattle | 1,788 | 5.0 | 18 |
| Tiki Barber | New York (G) | 1,656 | 5.0 | 17 |
| Rudi Johnson | Cincinnati | 1,588 | 4.4 | 14 |
| Edgerrin James | Arizona | 1,522 | 4.1 | 14 |
| Ronnie Brown | Miami | 1,517 | 4.3 | 11 |
| Carnell Williams | Tampa Bay | 1,508 | 4.1 | 9 |
| Steven Jackson | St. Louis | 1,505 | 4.4 | 14 |
| Clinton Portis | Washington | 1,493 | 4.1 | 10 |
| Warrick Dunn | Atlanta | 1,445 | 5.0 | 10 |
| LaDainian Tomlinson | San Diego | 1,441 | 4.4 | 9 |
| Julius Jones | Dallas | 1,428 | 4.3 | 11 |
| Reuben Droughns | Cleveland | 1,370 | 4.1 | 9 |
| Thomas Jones | Chicago | 1,351 | 4.4 | 9 |
| LaMont Jordan | Oakland | 1,350 | 4.1 | 8 |
| Domanick Davis | Houston | 1,327 | 4.0 | 8 |
| Willie Parker | Pittsburgh | 1,293 | 4.4 | 10 |
| Willis McGahee | Buffalo | 1,292 | 4.0 | 9 |
| Tatum Bell | Denver | 1,219 | 5.1 | 11 |
| Chester Taylor | Minnesota | 1,157 | 4.3 | 9 |
| Receiving Leaders | ||||
| Name | Team | Receptions | Yards | TDs |
| Steve Smith | Carolina | 102 | 1525 | 10 |
| Torry Holt | St. Louis | 99 | 1403 | 8 |
| Darrell Jackson | Seattle | 98 | 1280 | 8 |
| Chad Johnson | Cincinnati | 96 | 1469 | 9 |
| Javon Walker | Denver | 92 | 1335 | 8 |
| Anquan Boldin | Arizona | 89 | 1432 | 9 |
| Terrell Owens | Dallas | 89 | 1467 | 8 |
| Larry Fitzgerald | Arizona | 88 | 1357 | 8 |
| Hines Ward | Pittsburgh | 88 | 1240 | 8 |
| Reggie Wayne | Indianapolis | 85 | 1277 | 9 |
| Laveranues Coles | New York (J) | 84 | 1056 | 5 |
| Donald Driver | Green Bay | 84 | 1273 | 8 |
| Chris Chambers | Miami | 84 | 1236 | 8 |
| Lee Evans | Buffalo | 83 | 1259 | 7 |
| TJ Houshmandzadeh | Cincinnati | 83 | 1160 | 7 |
| Derrick Mason | Baltimore | 83 | 1101 | 6 |
| Rod Smith | Denver | 82 | 1057 | 6 |
| Deion Branch | New England | 81 | 1245 | 8 |
| Marvin Harrison | Indianapolis | 80 | 1162 | 8 |
| Roy Williams | Detroit | 76 | 1153 | 5 |
| Passing Leaders | ||||||
| Name | Team | Comps. | Comp. % | Yards | TDs | INTs |
| Peyton Manning | Indianapolis | 304 | 65% | 4365 | 32 | 18 |
| Eli Manning | New York (G) | 311 | 61% | 3947 | 26 | 18 |
| Trent Green | Kansas City | 299 | 61% | 3947 | 28 | 17 |
| Drew Bledsoe | Dallas | 271 | 58% | 3935 | 25 | 20 |
| Matt Hasselbeck | Seattle | 306 | 63% | 3877 | 26 | 14 |
| Tom Brady | New England | 268 | 60% | 3876 | 28 | 17 |
| Jake Delhomme | Carolina | 286 | 64% | 3779 | 28 | 18 |
| Carson Palmer | Cincinnati | 264 | 61% | 3575 | 25 | 9 |
| Marc Bulger | St. Louis | 237 | 62% | 3357 | 23 | 17 |
| Jake Plummer | Denver | 261 | 59% | 3351 | 21 | 11 |
| Drew Brees | New Orleans | 228 | 59% | 3347 | 22 | 17 |
| Donovan McNabb | Philadelphia | 261 | 61% | 3340 | 20 | 11 |
| Brad Johnson | Minnesota | 251 | 60% | 3309 | 21 | 11 |
| Brett Favre | Green Bay | 235 | 62% | 3234 | 22 | 20 |
| Ben Roethlisberger | Pittsburgh | 234 | 69% | 3149 | 22 | 13 |
| Charlie Frye | Cleveland | 227 | 57% | 3016 | 17 | 15 |
| Steve McNair | Baltimore | 224 | 57% | 2930 | 17 | 14 |
| Kurt Warner | Arizona | 195 | 62% | 2876 | 19 | 12 |
| Chris Simms | Tampa Bay | 220 | 57% | 2833 | 16 | 12 |
| Kelly Holcomb | Buffalo | 205 | 59% | 2824 | 18 | 15 |
| Tackling Leaders | ||
| Name | Team | Tackles |
| Jonathan Wilma | New York (J) | 133 |
| London Fletcher | Buffalo | 129 |
| Shelton Quarles | Tampa Bay | 128 |
| Keith Bulluck | Tennessee | 126 |
| Zach Thomas | Miami | 125 |
| Jeremiah Trotter | Philadelphia | 125 |
| Derrick Brooks | Tampa Bay | 124 |
| Andra Davis | Cleveland | 119 |
| Ray Lewis | Baltimore | 118 |
| Brian Urlacher | Chicago | 115 |
| Sack Leaders | ||
| Name | Team | Sacks |
| Derrick Burgess | Oakland | 14 |
| Simeon Rice | Tampa Bay | 14 |
| Osi Umenyiora | New York (G) | 13 |
| Michael Strahan | New York (G) | 13 |
| Dwight Freeney | Indianapolis | 13 |
| Jason Taylor | Miami | 12 |
| Bertrand Berry | Arizona | 12 |
| Shawne Merriman | San Diego | 12 |
| Robert Mathis | Indianapolis | 12 |
| Adewale Ogunleye | Chicago | 11 |
| Interception Leaders | ||
| Name | Team | Interceptions |
| Darren Sharper | Minnesota | 8 |
| Nathan Vasher | Chicago | 8 |
| Champ Bailey | Denver | 8 |
| Dre' Bly | Detroit | 6 |
| DeAngelo Hall | Atlanta | 6 |